Healthy Skin Models
Biomimiq’s portfolio of in vitro human skin equivalents (HSEs) is built on three basic epidermal and full-thickness models, suitable for a wide range of applications. All models can be customized to meet your specific demands.
Healthy Leiden epidermal skin model (LEM)
Epidermis-only • ECVAM pre-validated • Fast • Straightforward • Animal-free
Primary human keratinocytes are seeded on an inert acellular filter to proliferate and differentiate. The competent skin barrier function enables irritation and corrosivity screening as prescribed by EU standards.
Healthy full thickness fibroblast-derived matrix (FDM) model
Full thickness skin • Fully human • Long-term studies • Animal-free
Primary human keratinocytes are cultured on a human fibroblast-seeded dermal matrix. The resulting skin model is of full human origin and has superior resemblance to native skin. This model is particularly valued for long-term studies, as it is maintained in vitro for up to 20 weeks, in contrast to most other full thickness in vitro skin models, that are generally limited by a culture period of approximately 8 weeks. Biomimiq’s unique and highly representative FDM model enables studies focused on the natural interaction between human epidermis and dermis, including skin aging studies.
Healthy full thickness model (FTM)
Full thickness human skin • Fast & straighforward • Fullly customizable
Primary human keratinocytes are seeded on a human fibroblast-seeded collagen matrix and induced to proliferate and differentiate. The dermal matrix provides a functional microenvironment closely resembling native extracellular matrix, thereby stimulating the development of a fully differentiated epidermis. Biomimiq’s FTM is often successfully used to mimic skin diseases in vitro, by modulating the origin and genetic make-up of the epidermal and/or dermal cells incorporated in the model. Furthermore, the FTM enables studies on wound healing, dermal-epidermal interactions, and on the effect of external stimuli and chemical insults on the skin.