Healthy Skin Models

Biomimiq’s portfolio of in vitro human skin equivalents (HSEs) is built on three basic epidermal and full-thickness models, suitable for a wide range of applications. All models can be customized to meet your specific demands.

Healthy Leiden epidermal skin model (LEM)

Epidermis-only • ECVAM pre-validated • Fast • Straightforward • Animal-free


Primary human keratinocytes are seeded on an inert acellular filter to proliferate and differentiate. The competent skin barrier function enables irritation and corrosivity screening as prescribed by EU standards.


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Healthy full thickness fibroblast-derived matrix (FDM) model

Full thickness skin • Fully human • Long-term studies • Animal-free


Primary human keratinocytes are cultured on a human fibroblast-seeded dermal matrix. The resulting skin model is of full human origin and has superior resemblance to native skin. This model is particularly valued for long-term studies, as it is maintained in vitro for up to 20 weeks, in contrast to most other full thickness in vitro skin models, that are generally limited by a culture period of approximately 8 weeks. Biomimiq’s unique and highly representative FDM model enables studies focused on the natural interaction between human epidermis and dermis, including skin aging studies.


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Healthy full thickness model (FTM)

Full thickness human skin • Fast & straighforward • Fullly customizable

Primary human keratinocytes are seeded on a human fibroblast-seeded collagen matrix and induced to proliferate and differentiate. The dermal matrix provides a functional microenvironment closely resembling native extracellular matrix, thereby stimulating the development of a fully differentiated epidermis. Biomimiq’s FTM is often successfully used to mimic skin diseases in vitro, by modulating the origin and genetic make-up of the epidermal and/or dermal cells incorporated in the model. Furthermore, the FTM enables studies on wound healing, dermal-epidermal interactions, and on the effect of external stimuli and chemical insults on the skin.


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